Heart, Lung, Blood and Sleep Disorders: Courses and Conferences 2007

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Courses and Conferences - 2007

April - April 9th to 14th
Comprehensive Approaches to the in vivo Assessment of Cardiovascular Function in Mice

The workshop focuses on the assessment of cardiovascular function in mouse models. This is a comprehensive program which includes didactic lectures by leaders in the field of cardiovascular physiology, pharmacology and pathology, followed by four days of hands on workshops. Day 2 will focus on non-invasive high-resolution ultrasound using the Visualsonics Vevo 770 system, whereas day 3 and 4 will cover telemetry (DataSciences International) and catheter-dependent (ADInstruments) approaches to monitoring cardiovascular parameters in vivo. The final day will cover methods for analyzing data collected during the course of the workshop and will include study design and statistical analysis. Surgical and anesthesic techniques will also be taught.

Please also see the PGA Traveling Tutorial in Baltimore - April 17th-18th

Please click here for more information.

August - Agust 3rd to 11th
Genomic and Proteomic Approaches to Complex Heart, Lung, Blood, & Sleep Disorders

This highly acclaimed course covers the application of statistics, molecular biology and genetics to the analysis of complex diseases such as asthma, hypertension, and coronary heart disease. Both human and animal model data are presented and considered in-depth.

Students learn to detect the genetic basis of disease, perform linkage analysis, conduct genome scans, analyze quantitative trait loci, detect gene interactions, map complex disease genes, buand clone genes. Emphasis is also placed on how to characterize gene function using the latest in biochemical and molecular genetic techniques. Contemporary approaches to gene discovery such as mutagenesis, microarray analysis, comparative genomics, and SNP discovery and analysis are also covered. Social and ethical issues surrounding the generation and use of genetic information are discussed during the course.

Intensive hands-on workshops further expose students to the bioinformatics tools such as: Omim, MGD, Unigene, GeneBank, Blast, Gene-scan, SwissProt and Entrez.

September - September 9th to 14th
Workshop on Modeling Pulmonary Function in Mice

This workshop will feature the advanced technologies currently used by the field's top researchers. Applications will be reviewed on a competitive selection basis until the course is filled. Enrollment is limited to 16. Applications by women, minorities, and persons with disabilities are strongly encouraged.

Other workshops and courses in 2007 at The Jackson Laboratory that may be of interest to HLBS disorders research personnel are:

48th Annual Short Course on Medical and Experimental Mammalian Genetics See the 2006 schedule for information on the type of presentations

Short Course 0n Complex Trait Analysis See the 2006 schedule for information on the type of presentations

Courses and Conferences - 2006

Workshops and courses in 2006 at The Jackson Laboratory that may have been of interest to HLBS disorders research personnel were:

47th Annual Short Course on Medical and Experimental Mammalian Genetics - Schedule

Short Course 0n Complex Trait Analysis - Schedule

11th Annual Short Course on Genetic Approaches To Complex Heart, Lung, And Blood Diseases - Oct 19, 2006 - Oct 28, 2006 - The presentations will be posted soon.

Courses and Conferences - 2005

Discovery Strategies 2005: Improving the predictive value of mouse models in drug discovery and development: May 16, 2005 - May 18, 2005

Last year's Discovery Strategies Conference highlighted the laboratory mouse as a predictive tool in the drug discovery and development process. A central theme was improving concordance between model systems and human, and the emerging role of mice in assessing drug safety and clinical efficacy. Thought leaders presented and discussed cutting-edge methods used to identify potential drug targets and elucidate the mechanisms and pathways by which xenobiotics elicit both desirable and undesirable effects. Presentations included the use of QTL analysis and in silico mapping to identify key pathway components that underlie phenotypes associated with both disease and clinical response to pharmaceutical compounds. Other technologies such as RNAi, and gene trapping and targeting were explored.

Short Course on Genetic Approaches To Complex Heart, Lung, Blood and Sleep Disorders: September 23rd to October 2nd

This course focuses gene expression analysis in a variety of mouse models relevant to the study of heart, lung, blood and associated sleep disorders. Participants will be introduced to wet bench methods necessary for the preparation of expression chips including nucleic acid extraction, isolation and purification protocols, analytical approaches to chip reading and data analysis, software tools, and case-oriented application of microarray technology to heart, lung, blood and associated sleep disorders.

Short Course 0n Complex Trait Analysis: Oct 5, 2005 - Oct 11, 2005

This course demonstrates statistical genetic models, software tools, and important biological problems illustrated by the use of real data. Biological questions will be framed largely around a variety of human disease-related traits including, but not limited to, cancer, diabetes, hypertension, osteoporosis and obesity. Key concepts that will be addressed include the relationships between genotype and phenotype, transmission genetics, population genetics, gene action and interaction, genetic and physical mapping, experimental designs for genetic mapping in model organisms, and sampling issues in human studies.

Frontiers in Gene Expression Analysis: Oct 24, 2005 - Oct 28, 2005

This course will focus primarily on gene expression analysis in a variety of mouse models relevant to the study of heart, lung, blood and associated sleep disorders. Participants will be introduced to wet bench methods necessary for the preparation of expression chips including nucleic acid extraction, isolation and purification protocols, analytical approaches to chip reading and data analysis, software tools, and case-oriented application of microarray technology to heart, lung, blood and associated sleep disorders.

Courses and Conferences - 2004

Short Course on Gene Microarray Development and Analysis: Approaches to Heart, Lung, Blood and Sleep Disorders: Spring Course: April 17-22

The course focuses gene expression analysis in a variety of mouse models relevant to the study of heart, lung, blood and associated sleep disorders. Participants will be introduced to wet bench methods necessary for the preparation of expression chips including nucleic acid extraction, isolation and purification protocols, analytical approaches to chip reading and data analysis, software tools, and case-oriented application of microarray technology to heart, lung, blood and associated sleep disorders.

Workshop on Phenotyping New Mouse Models for Heart, Lung, Blood and Sleep Diseases: Spring Workshop: April 25-29

This workshop provides hands-on training in phenotyping mouse mutants for cardiovascular defects, and heart, lung, blood and sleep disorders. The program will focus primarily on blood pressure measurement, ultrasound, EKG and coagulation profiles, and the theory and methods used in the screening of sleep and respiratory mutants.

Participants will practice clean room technique and will learn techniques currently used to phenotype new mutants generated at this facility. Didactic sessions will include genetics, mutagenesis and breeding strategies and new bioinformatics paradigms for investigators in heart, lung, blood and sleep disorders research. This workshop is appropriate for graduate students, postdoctoral fellows and established investigators wishing to learn state-of-the-art techniques in phenotyping heart, lung, blood and sleep defects that are particularly relevant to human health.

Short Course on Gene Microarray Development and Analysis: Approaches to Heart, Lung, Blood and Sleep Disorders: Nov 6, 2004 - Nov 11, 2004

The course will focus primarily on gene expression analysis in a variety of mouse models relevant to the study of heart, lung, blood and associated sleep disorders. Participants will be introduced to wet bench methods necessary for the preparation of expression chips including nucleic acid extraction, isolation and purification protocols, analytical approaches to chip reading and data analysis, software tools, and case-oriented application of microarray technology to heart, lung, blood and associated sleep disorders.

Short Course on Genetic Approaches to Complex Heart Lung and Blood Diseases: Oct 7, 2004 - Oct 15, 2004

During nine days of intensive training and tutoring, this highly acclaimed course covers the application of statistics, molecular biology and genetics to the analysis of complex diseases such as asthma, hypertension, and coronary heart disease. Both human and animal model data are presented and considered in-depth.

The course consists of formal lectures, discussion groups, demonstrations and tutorials, with some afternoons left open for recreational purposes. Students reside on-site at The Highseas Conference Center at The Jackson Laboratory in Bar Harbor, Maine.

This course is approved for up to 52 hours of Continuing Medical Education credit through the Maine Medical Center. The Maine Medical Center is accredited by the Maine Medical Association to provide continuing medical education for physicians.

Courses and Conferences - 2003

Techniques in Gene Microarray Development and Analysis: Approaches to Heart, Lung, Blood and Sleep Disorders: Spring Course: April 22-26 and Fall Course: November 8-12

Workshop on Phenotyping New Mouse Models for Heart, Lung, Blood and Sleep Disorders May 6-10:

Genetic Approaches to Complex Heart, Lung, and Blood Diseases September 11-19:

This short course focuses on mathematical approaches to studying complex diseases in humans using the mouse as a paradigm. The course covers a variety of topical diseases, including cancer, obesity and diabetes as well as diseases with an epidemiological component such as AIDS. The emphasis is on training both mathematicians and biologists in this increasingly important area. Biologists will walk away with a clearer understanding of the tools available for genomic applications, and mathematicians will gain an appreciation of contemporary computational problems in modern genetics and applied genomics.

Courses and Conferences - 2002

Short Course on Gene Microarray Development and Analysis: Approaches to Heart, Lung, Blood and Sleep Disorders, April 24-28, 2002.

This workshop provides intensive hands-on training in the preparation and analysis of gene chips. The focus of this workshop is on microarray approaches to the study of heart, lung, and blood disease and associated sleep disorders.

Workshop on Phenotyping New Mouse Models for Heart, Lung, Blood and Sleep Disorders, May 1 - 4, 2002.

This workshop is designed to teach current phenotyping protocols used to screen new mouse mutant models for the study of heart, lung, blood and sleep disorders. The course consists of both didactic and practical hands-on sessions.

Short Course on Mathematical Approaches to the Analysis of Complex Phenotypes, September 18-25, 2002.

This short course will focus on mathematical approaches to complex disease in humans using the mouse as a model. A variety of disease areas are taken as practical examples including cancer, obesity and diabetes as well as diseases with an epidemiological component such as AIDS. The emphasis is on training mathematicians and biologists alike in the application of statistics and genetics to the study of human disease.

Short Course on Genetic Approaches to the Analysis of Complex Heart Lung and Blood Diseases, September 27 - October 6, 2002.

This short course focuses on genetic approaches to complex heart, lung and blood diseases and includes techniques used to analyze human population data and data derived from genetic experiments done in the laboratory mouse.

Short Course on Gene Miroarray Development and Analysis: Approaches to Heart, Lung, Blood and Sleep Disorders, November 3-7, 2002.

Workshop on Phenotyping New Mouse Models for Heart, Lung, Blood and Sleep Disorders, November 9-12, 2002.

Program for Genomic Applications (PGA)

Supported by the National Heart, Lung, and Blood Institute (NHLBI) (Grant # HL66611)

The Jackson Laboratory