Sleep Phenotypes

ESO
ESL
ESD 		Excessively Sleepy: Overall; in the Light; in the Dark; (longer and/or more sleep bouts in one or both periods)
EWO
EWL
EWD
Excessively Wakeful: Overall; Light; Dark (shorter and/or fewer sleep bouts in one or both periods)

FO
FL
FD

Fragmented: Overall; Light; Dark (more sleep and wake bouts with short duration in one or both periods)

CSL
 
Consolidated Sleep in the Light period (increased sleep bout durations in the light period)


Defining Sleep in Mice

Using data from 3-day cage test (CCMS)

• 2 photoperiods: Light (L) and Dark (D)

  • For each photoperiod per day we define:
    total sleep (S) (minutes)
    total wake (W) (min)
    # sleep bouts
    average sleep bout (SB) duration (min)
    average wake bout (WB) duration (min)

    The following are average values and standard deviations for strain C57BL/6J:
Males L_Sleep L_Wake L_SBouts L_WBouts AvgLSB AvgLWB D_Sleep D_Wake D_SBouts D_WBouts AvgDSB AvgDWB
Mean 466.8 253.2 158.6 158.9 3.0 1.6 267.3 452.7 127.7 127.9 2.1 3.7
SD 30.7 30.7 22.3 22.3 0.5 0.3 46.2 46.2 22.6 22.6 0.4 1.0
+ 2.5 SD 543.5 329.9 214.3 214.7 4.3 2.3 382.7 568.2 184.1 184.4 3.0 6.1
- 2.5 SD 390.1 176.5 102.8 103.2 1.7 1.0 151.8 337.3 71.3 71.5 1.2 1.4
Females
Mean 432.0 288.0 187.0 187.5 2.3 1.6 250.9 469.1 133.3 133.5 1.9 3.7
SD 29.0 29.0 17.5 17.5 0.3 0.2 54.8 54.8 23.2 23.2 0.2 1.0
+ 2.5 SD 504.6 360.6 230.8 231.2 3.0 2.1 387.9 606.2 191.4 191.5 2.5 6.3
- 2.5 SD 359.4 215.4 143.2 143.8 1.7 1.0 113.8 332.1 75.2 75.6 1.3 1.2

n = 100 per gender; Outliers are identified by values > 2.5 SD from B6 mean