HLBS Phenotypic Deviant Report

HLB # 414
MGI Accession # Pending
Mouse Identifier 63118
Date Mouse Born 2/25/04
Sex Male
Genetic Background C57BL/6J
Mutagen ENU (See ENU Treatment Protocol)
Phenotype Index Lung function: Airway hyper-response. Note: This phenotype will be validated by an evaluation of the airway pressure-time index (APTI) to substantiate the initial suggestion of airway hyper-response.
Phenotype Description

At 9 weeks of age this mouse showed a hyper-response to Methacholine (MCH) challenge.

1st run Absolute Penh values were:

Confirmatory run Absolute Penh values were:

Saline =0.46
MCH:

·  5 mg/ml = 0.64

·  10 mg/ml = 0.92

·  20 mg/ml =4.54

Saline = 0.66
MCH:

·  5 mg/ml =0.60

·  10 mg/ml = 1.28

·  20 mg/ml =12.48
Other information No other likewise affected animals identified from this pedigree to date.
Heritability The heritability of this phenotype is being confirmed.
Chromosome Unknown
Inheritance Unknown
Molecular Interval Unknown
Date Posted 6/17/04
Availability Not yet available. If you are interested in this phenotype please email us.

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Program for Genomic Applications (PGA)

Supported by the National Heart, Lung, and Blood Institute (NHLBI) (Grant # HL66611)