HLBS Phenotypic Deviant Report

HLB # 454
MGI Accession # Pending
Mouse Identifier 74517
Date Mouse Born 9/12/04
Sex Male
Genetic Background C57BL/6J
Mutagen ENU (See ENU Treatment Protocol)
Phenotype Index Lung function: Airway hyper-response as measured by whole body plethysmography. Note: This phenotype has been validated by an invasive resistance evaluation using a flexivent protocol.  See graph below showing 3 animals from this line as well as control C57BL/6J animals.            See previous results here.
Phenotype Description At 9 weeks of age, during the first week consuming the atherogenic diet, this mouse showed a hyper-response to Methacholine (MCH) challenge.

1st run Absolute Penh values were: Confirmatory run Absolute Penh values were:
  • 5 mg/ml = 1.37
  • 10 mg/ml = 2.01
  • 20 mg/ml = 11.47
  • Saline = 0.50MCH:
  • 5 mg/ml = 0.98
  • 10 mg/ml = 1.94
  • 20 mg/ml = 5.29

 

 
Other information Male sibling 74518 also responsive.
Phenotype confirmed by flexivent and report updated 1/31/07
Heritability The heritability of this phenotype is being confirmed.
Chromosome Unknown
Inheritance Recessive
Molecular Interval Unknown
Date Posted 2/4/05
Availability Not yet available. Email us for more information.

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Supported by the National Heart, Lung, and Blood Institute (NHLBI) (Grant # HL66611)