Jax-PGA Investigators' HLBS related publications, manuscripts & book chapters:

Genetic resources:

Svenson K, Smith RV, Magnani P, Suetin H , Paigen B, Naggert JK, Li R, Churchill GA, and Peters L.  Multiple Trait Measurements in 43 Inbred Mouse Strains Captures the Phenotypic Diversity Characteristic of Human Populations. J Appl Physiol (February 22, 2007). doi:10.1152/japplphysiol.01077.2006

Korstanje R, Paigen B. 2002. From QTL to gene: The harvest begins. Nat Genet. 31:235-236.

Li R, Lyons MA, Wittenburg H, Paigen B, Churchill GA. 2005. Combining Data from Multiple Inbred Line Crosses Improves the Power and Resolution of QTL Mapping. Genetics, Mar;169(3):1699-709. Epub 2005 Jan 16.

Cardio:

Sugiyama F, Churchill GA, Li R, Libby LJ, Carver T, Yagami K, John SW, Paigen B. 2002. QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice. Physiol Genomics 10:5-12.

Wang X, Paigen B. 2002. Comparative genetics of atherosclerosis and restenosis: Exploration with mouse models. Arterioscler Thromb Vasc Biol 22:884-886.

Wang X and Paigen B. 2002. Quantitative trait loci and candidate genes regulating HDL cholesterol. Arterioscler Thromb Vasc Biol 22:1390-1401.

Svenson KL, Bogue MA, Peters LL. 2003. Invited Review: Identifying new mouse models of cardiovascular disease: A review of high-throughput screens of mutagenized and inbred strains. J Appl Physiol 94:1650-1659.

Blood:

Peters LL, Cheever EM, Ellis HR, Magnani P, Svenson KL, Smith RV, Bogue M. 2002. Large scale, high throughput screening for coagulation and hematologic phenotypes in mice. Physiol Gen 11:185-193.

Peters LL, Zhang W, Lambert AJ, Brugnara C, Churchill GA, Platt OS. 2005. Quantitative trait loci for baseline white blood cell count, platelet count, and mean platelet volume. Mamm Genome16, 749-763.

Inoue Y, Peters LL, Yim SH, Inoue J, Gonzalez FJ. 200_. Hepatocyte nuclear factor 4a is critical for blood coagulation homeostasis. J. Mol. Med, in press.

Yang SH, Shrivastav A, Kosinski C, Sharma RK, Chen MH, Berthiaume LG.
Peters LL, Chuang P-T, Young SG, Bergo MO. 2005. N-Myristoyltransferase 1 is essential for early mouse development. J Biol Chem 280:18990-18995.

QTL:

Lorenz E, Jones M, Wohlford-Lenane C, Meyer N, Frees KL, Schwartz DA. 2000. Genes, other than TLR4, are involved in the response to LPS. Am J Hum Genet; 67(4):367.

Lung:

Lorenz E, Jones M, Wohlford-Lenane C, Meyer N, Frees KL, Arbour NC, Schwartz DA. 2001. Genes other than TLR4 are involved in the response to inhaled LPS. Am J Physiol Lung Cell Mol Physiol 281(5):L1106-1114.

Schwartz DA. 2002. The genetics of innate immunity. Chest 121:62S-68S.

Cook DN, Brass DM, Schwartz DA. 2002. A matrix for new ideas in pulmonary fibrosis. Amer J Respir Cell Mol Biol 27:122-124.

Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Willeit J, Schwartz DA. 2002. Toll-like receptor 4 mutations and atherogenesis in humans. N Engl J Med 347(3):185-192.

Moreland JG, Fuhrman RM, Pruessner JA, Schwartz DA. 2002. CD11b and ICAM-1 are essential to pulmonary neutrophil recruitment in LPS-induced airway disease. Am J Respir Cell Mol Biol 27(4): 474-480.

Svenson KL, Bogue MA, Peters LL. 2003. Identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred mice. J App Physiol 94: 1650-1659.

Whitehead GS, Walker JKL, Berman KG, Foster WM, Schwartz DA. 2003. Allergen induced airway disease is mouse strain dependent. Am J Physiol: Lung Cell Mol Physiol285: L32-42.

Balmes J, Becklake M, Blanc P, Henneberger P, Kreiss K, Mapp C, Milton D, Schwartz D, Toren K, Viegi G. 2003. ATS statement on occupational contribution to the burden of airway disease. Am J Resp Crit Care Med 167(5):787-797.

Brass DM, Savov JD, Gavett SH, Haykal-Coates N, Schwartz DA. 2003. Subchronic endotoxin inhalation causes chronic airway disease. Am J Physiol: Lung Cell Mol Physiol 285: L755-L761.

Walker, JKL, Fong AM, Lawson BL, Savov JD, Patel DD, Schwartz DA, Lefkowitz RJ. 2003. b-arrestin-2 regulates the development of allergic asthma. J Clin Invest 112:566-574.

Palmer SM, Burch LH, Davis RD, Herczyk WF, Howell DN, Reinsmoen NL, Schwartz DA. 2003. The role of innate immunity in acute allograft rejection after lung transplantation. Am J Respir Crit Care Med 168(6):628-632.

Savov JD, Brass DM, Berman KG, McElvania E, Schwartz DA. 2003. Fibrinolysis in LPS induced chronic airway disease. Am J Physiol: Lung Cell Mol Physiol 285(4):L940-L948.

Sleep:

Pack AI, Galante RJ, Maislin G, Cater J, Metaxas D, Lu S, Zhang L, Von Smith R, Kay T, Lian J, Svenson K, Peters LL. 2007. Novel method for high-throughput phenotyping of sleep in mice. Physiol Genomics. Jan 17;28(2):232-8. Epub 2006 Sep 19.

Graves LA, Hellman K, Veasey S, Blendy JA, Pack AI and Abel T. 2003. Genetic evidence for a role of CREB in sustained cortical arousal. J. Neurophysiol. 90:1152-1159.

Galante RJ, Metaxes D, Lu S, Lian J, Zhang L, and Pack AI. 2003. Can direct digital video analysis of mice be used as a non-invasive high throughput phenotyping strategy to estimate durations of sleep and wake? Sleep 26:A418.

Mutagenesis/Phenotyping:

O'Brien TP. 2002. Mutagenesis and genetic screens in the mouse. In: Systematic Evaluation of the Mouse Eye: Anatomy, pathology, and biomethods, Smith RS, John SWM, Nishina PM, Sundberg JP (eds), CRC Press, pp. 93-108.

Frank AC, Meyers K A, Welsh IC and O'Brien TP. 2003. Development of an EGFP-based Dual-Color Reporter to Facilitate Genetic Screens for the Recovery of Mutations in Mice. PNAS USA 100: 14103-14108.